A regenerating poison beast: poisons whole groups and steps back while they melt.

| Health | 160 (+48 per level) |
| Base damage | 15 (+3 per level) |
| Armour | 20 |
| Speed | 7 m/s |
| Difficulty | Medium |
| Tier | S · Strong late into Monsoon and long runs, and forgiving. |
On victory: «..and so it left, with delusions of freedom.»
Challenge «...To Be Left Alone»: Stabilize the Cell in the Void Fields. (40.6% of Steam players have it).
Damage is a percentage of your normal damage: 100% is a normal hit; 300% is triple.

Some attacks poison: poison drains a lot of health over time but never finishes the enemy off.

Instead of poison, blight: weaker (60% per second) but it stacks and can kill. Better against bosses.
To get it: As Acrid, land the killing blow on 50 total enemies that have 1 hit point left (23.2% of Steam players have it).

Claw swipes of 200%. Every third hit does 400% and heals you.

You spit acid at range: 240% and poisons.

A 310% bite that poisons, heals you, and hits harder the less health the enemy has.
To get it: As Acrid, land the final blow on a Scavenger (13% of Steam players have it).

You leap and land for 320%, stunning and poisoning, and leave an acid puddle.

You leap and land for 550% and stun. Each enemy hit brings the leap back sooner (2 s off the cooldown).
To get it: As Acrid, inflict Poison 1000 total times (15.6% of Steam players have it).

A disease that jumps from enemy to enemy, up to 20, hurting all of them. Best against groups.

You breathe out a poison cloud that stays put: 240% per second to anyone inside.
To get it: As Acrid, beat the game after sequencing your items at least once (0.5% of Steam players have it).
Poison+
Vicious Wounds+
Neurotoxin+
Caustic Leap+
Epidemic
Focus Crystal
Boosts Poison and Blight damage.
You do 20% more damage to enemies close to you (within 13 m). Each extra crystal adds 20%.
Stacking: Each copy adds the same, no cap.
Watch out: It also boosts burn and bleed damage on nearby enemies.

Armor-Piercing Rounds
More Poison damage to bosses.
You do 20% more damage to bosses. Each extra one adds 20%.
Stacking: Each copy adds the same, no cap.
Watch out: Only works on enemies with a red health bar (bosses).

Death Mark
Poison counts as one of the 4 debuffs it needs.
An enemy with 4 or more bad effects on it (burning, bleeding, slowed...) takes 50% more damage from everything. Each extra mark lasts longer.
Stacking: Each copy adds the same, no cap.
Watch out: Your allies benefit from the mark too. Damage over time cannot apply it.

Shattering Justice
Raises all damage, Poison included.
Hit an enemy 5 times and you break its armour, so it takes more damage for 8 s. Each extra one, 8 s more.
Stacking: Each copy adds the same, no cap.
Watch out: Good on almost anyone: lowering armour raises all damage a lot.

Alien Head
With Blight, using more skills puts more blight on the enemy.
All your skills come back 25% sooner. Each extra head, another 25% less.
Stacking: Each copy cuts a share of what is left: it drops less each time and never reaches zero.
Watch out: It applies before Purity: together they cut cooldowns a lot.

Challenge «...To Be Left Alone»: Stabilize the Cell in the Void Fields. (40.6% of Steam players have it).
We recommend Poison, Vicious Wounds, Neurotoxin, Caustic Leap, Epidemic.
Focus Crystal, Armor-Piercing Rounds, Death Mark, Shattering Justice, Alien Head.
Sources: Risk of Rain 2 game names and challenges, the Risk of Rain 2 wiki (stats, cooldowns and tips); the explanations are our own and public Steam statistics, as of 31 October 2026. The tier is our own. Icons: Risk of Rain 2 (Hopoo Games / Gearbox).