Drop from legendary chests and, less often, from large and small chests. A good run has only a few.
In alphabetical order. Each one says what it does and what happens if you take more than one. Which ones are worth it: the item tier list.
57 Leaf Clover
Everything based on chance is rolled twice and you keep the best: more crits, more item effects. Each extra clover, one more roll.
Stacking: Each copy adds the same, no cap.
Watch out: Does not affect Tougher Times. Each Purity cancels out one Clover.
Needs unlocking first (challenge «The Long Road»).

Aegis
Healing beyond your max health turns into a layer of temporary health. Each extra one, a bigger layer.
Stacking: Each copy adds the same, no cap.

Alien Head
All your skills come back 25% sooner. Each extra head, another 25% less.
Stacking: Each copy cuts a share of what is left: it drops less each time and never reaches zero.
Watch out: It applies before Purity: together they cut cooldowns a lot.

Ben's Raincoat
Blocks one bad effect (burn, poison...) and gives you a layer of temporary health instead. Recharges every 5 s. Each extra one, one more effect.
Stacking: Each copy adds the same, no cap.
Watch out: Only timed debuffs: not void fog nor Tonic Afflictions.

Bottled Chaos
Using your equipment also triggers a random other equipment effect. Each extra one, one more effect.
Stacking: Each copy adds the same, no cap.
Watch out: Some equipment never rolls: Glowing Meteorite, Helfire Tincture, Effigy of Grief, Spinel Tonic.

Brainstalks
Killing an elite gives you 4 s with no cooldowns: use your skills non-stop. Each extra one, 4 s more.
Stacking: Each copy adds the same, no cap.
Watch out: Not zero cooldown: half a second remains.
Needs unlocking first (challenge «Deicide»).

Brilliant Behemoth
All your attacks explode and hurt nearby enemies. Turns any attack into an area attack. Each extra one, a bigger explosion.
Stacking: Each copy makes the blast bigger; damage does not go up.
Watch out: The blast copies the hit: if Lost Seer's Lenses instantly kill something, the blast can also kill a boss standing next to it.

Ceremonial Dagger
Every kill fires 3 daggers that chase other enemies. It chains kills on its own. Each extra one, stronger daggers.
Stacking: Each copy adds the same, no cap.
Watch out: The daggers do not avoid walls and get stuck.

Defensive Microbots
Tiny robots shoot down enemy projectiles that get close. Each extra one, one more per shot.
Stacking: Each copy adds the same, no cap.
Watch out: It cannot stop hitscan attacks (golem lasers). Outside Captain, only artifacts can give it.

Dio's Best Friend
An extra life: if you die, you come back with 3 seconds of being untouchable. It is used up.
Stacking: One extra life per copy; used up on revive.
Needs unlocking first (challenge «The Lone Survivor»).

Electric Boomerang
Sometimes you throw an electric boomerang that goes through enemies, stuns and comes back. Each extra one, more damage.
Stacking: Each copy adds the same, no cap.
Watch out: It can get stuck in terrain and hit nearby enemies many times.

Frost Relic
Kills surround you with an ice storm that hurts and slows enemies; it grows with every kill. Each extra relic, bigger.
Stacking: Each copy raises the storm's maximum size.

Growth Nectar
For each good effect on you, all your stats go up 4%, up to 4. Each extra one raises the cap.
Stacking: Each copy raises the buff cap.
Watch out: It multiplies what you already have: with no crit or armour, those barely go up.

H3AD-5T v2
You jump higher and landing causes a huge blast: the higher you fall from, the harder it hits. Each extra one, faster recharge.
Stacking: Each copy lowers the cooldown, less each time.

Happiest Mask
Enemies you kill sometimes come back as ghosts that fight for you for 30 s. Each extra mask, 30 s more.
Stacking: The chance stays at 7%; each copy adds 30 s of ghost.
Watch out: Some ghosts can still hurt or kill you (Lynx Totem, Grandparent).

Hardlight Afterburner
Your movement skill (Shift) gets two more uses and comes back sooner. Each extra one, two more uses.
Stacking: Each copy, two more charges.

Interstellar Desk Plant
Kills plant a seed that becomes a healing plant after 5 s for you and nearby allies. Each extra one, a bigger area.
Stacking: Each copy adds the same, no cap.
Watch out: The real radius is twice what the game says (10 m).

Laser Scope
Your crits do triple damage instead of double. Each extra scope, another 100%.
Stacking: Each copy adds the same, no cap.
Watch out: On Railgunner it is worth ten Glasses.

N'kuhana's Opinion
Your healing is stored up and, when there is enough, a skull fires out that chases and hits hard. Each extra one, more damage.
Stacking: Each copy adds the same, no cap.
Watch out: Shields count as health. At most 10 skulls per second, and it fires even with no enemies around.
Needs unlocking first (challenge «Her Concepts»).

Networked Suffering
You infect up to 4 enemies: part of the damage they take is pooled and every 3 s it hits all of them at once. Each extra one, 2 more enemies.
Stacking: Each copy adds the same, no cap.
Watch out: It pools everyone's damage, allies and damage over time included.

Orphaned Core
A friendly robot rams enemies; the faster you are, the harder it hits. Pet it to clear bad effects. Each extra one, more damage.
Stacking: Each copy adds the same, no cap.
Watch out: The robot inherits your speed items (Hoof, Energy Drink, Mocha, Warbanner...).

Pocket I.C.B.M.
Everything that fires missiles fires 2 more. Each extra one, stronger missiles.
Stacking: The 2 extra missiles are fixed; from the second copy on, each adds 50% missile damage.
Watch out: Works with AtG Missile, Fireworks, Plasma Shrimp and War Bonds (with War Bonds, the extras deal half).

Rejuvenation Rack
All your healing is doubled. Each extra rack, more again.
Stacking: Each copy adds the same, no cap.
Needs unlocking first (challenge «Naturopath»).

Resonance Disc
Kill 4 enemies in 7 seconds and a disc flies out, goes through enemies, explodes and comes back. Each extra one, more damage.
Stacking: Each copy adds the same, no cap.
Watch out: The explosion deals 4 times what the game says.

Runic Lens
Your hits sometimes call down a huge meteor; the bigger the hit, the likelier and stronger. Each extra lens, more again.
Stacking: Each copy adds the same, no cap.
Watch out: Capped at 75% chance and 7500% damage. Only one meteor at a time.

Sentient Meat Hook
20% of your hits fire hooks that chase up to 10 enemies. Each extra hook, more likely and more enemies.
Stacking: The chance adds less each time (never 100%); targets add the same.
Needs unlocking first (challenge «Deja Vu?»).

Shattering Justice
Hit an enemy 5 times and you break its armour, so it takes more damage for 8 s. Each extra one, 8 s more.
Stacking: Each copy adds the same, no cap.
Watch out: Good on almost anyone: lowering armour raises all damage a lot.

Soulbound Catalyst
Every kill recharges your equipment sooner (4 s less). Each extra one, 2 s more.
Stacking: Each copy adds the same, no cap.
Watch out: Useless with equipment that has no cooldown. Turret kills do not count.
Needs unlocking first (challenge «Newtist»).

Spare Drone Parts
Your drones attack faster, fire missiles and get a chain gun. You also get a drone. Each extra one, faster drones.
Stacking: Speed adds the same; drone cooldowns drop less each time.
Watch out: Works on all your mechanical allies, turrets included.

Substandard Duplicator
Picking up an item gives you a temporary copy that lasts a while. Not with printers. Each extra one, they last longer.
Stacking: Each copy adds the same, no cap.
Watch out: Does not work on printed items. Lunar items are never copied.

Symbiotic Scorpion
Each hit permanently strips a bit of the enemy's armour: the more you hit it, the more damage it takes. Each extra one, strips more.
Stacking: Each copy adds the same, no cap.
Watch out: «Permanent» only lasts the stage: it resets when you move on.

Unstable Tesla Coil
You fire constant lightning at 3 nearby enemies; it switches off every 10 s and comes back. Each extra coil, 2 more enemies.
Stacking: Each coil, 2 more targets.
Needs unlocking first (challenge «Macho»).

Wake of Vultures
Killing an elite (the coloured ones) gives you its power for a few seconds (fire, ice, lightning...). Each extra one, longer.
Stacking: Each copy adds the same, no cap.
Watch out: You can have every elite power at once.

War Bonds
During boss fights, missiles rain down and take a chunk of their health. The more gold you earn before, the more missiles. Each extra one, more damage.
Stacking: Each copy adds the same, no cap.
Watch out: Its missiles do not proc items. Four can take out a whole phase of the final boss.

Other rarities: Common items · Uncommon items · Boss items · Void items · Lunar items.
34, including expansion items.
Almost always the effect grows: each copy adds a bit more. Every item on this page says what it adds. For a few (like Tougher Times) each copy adds a little less than the one before.
Sources: Risk of Rain 2 game text and the Risk of Rain 2 wiki (rarities and unlocks), as of 31 October 2026. Icons: Risk of Rain 2 (Hopoo Games / Gearbox).